Are the integrin binding motifs within SARS CoV-2 spike protein and MHC class II alleles playing the key role in COVID-19?

The previous studies on the RGD motif (aa403-405) within SARS CoV-2 spike (S) protein receptor binding domain (RBD) suggest that integrin(s) may play an important role in infection of host cells. We also discussed possible two other integrin motifs are present S protein: LDI (aa585-587) and ECD (661-663), used by some viruses course infection. MultiFOLD models for structure analysis have shown is clearly accessible protein, whereas partially accessible. Furthermore, amino acids Epstein-Barr virus (EBV) gp42 playing very to HLA-DRB1 molecule subsequent immune response evasion, heptad repeat-2. Our model analyses these surface each chain as monomers homotrimer complex bind β chain. Therefore, they identical evasion EBV prediction MHC class II peptides core 9-mer peptide IRGDEVRQI HLA-DRB1*03:01 HLA-DRB3*01.01 strong 15-mer suggesting be potential epitope. Accordingly, infected or positive individuals develop high affinity anti-RGD antibodies react with proteins, like fibrinogen, thrombin von Willebrand factor, affecting haemostasis participating autoimmune disorders.